The microtubule-severing protein UNC-45A preferentially binds to curved microtubules and counteracts the microtubule-straightening effects of Taxol

Uncoordinated protein 45A (UNC-45A) is the only known ATP-independent microtubule (MT)-severing protein. Thus, it severs MTs via a novel mechanism. In vitro and in cells, UNC-45A–mediated MT severing is preceded by the appearance of MT bends. While MTs are stiff biological polymers, in cells, they o...

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Detalles Bibliográficos
Autores principales: Hoshino, Asumi, Clemente, Valentino, Shetty, Mihir, Castle, Brian, Odde, David, Bazzaro, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654038/
https://www.ncbi.nlm.nih.gov/pubmed/37858676
http://dx.doi.org/10.1016/j.jbc.2023.105355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654038/
https://www.ncbi.nlm.nih.gov/pubmed/37858676
http://dx.doi.org/10.1016/j.jbc.2023.105355

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