Mitoribosomal synthetic lethality overcomes multidrug resistance in MYC-driven neuroblastoma

Mitochondria are central for cancer responses to therapy-induced stress signals. Refractory tumors often show attenuated sensitivity to apoptotic signaling, yet clinically relevant molecular actors to target mitochondria-mediated resistance remain elusive. Here, we show that MYC-driven neuroblastoma...

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Detalles Bibliográficos
Autores principales: Borankova, Karolina, Krchniakova, Maria, Leck, Lionel Y. W., Kubistova, Adela, Neradil, Jakub, Jansson, Patric J., Hogarty, Michael D., Skoda, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654511/
https://www.ncbi.nlm.nih.gov/pubmed/37973789
http://dx.doi.org/10.1038/s41419-023-06278-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654511/
https://www.ncbi.nlm.nih.gov/pubmed/37973789
http://dx.doi.org/10.1038/s41419-023-06278-x

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