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Mitoribosomal synthetic lethality overcomes multidrug resistance in MYC-driven neuroblastoma
Mitochondria are central for cancer responses to therapy-induced stress signals. Refractory tumors often show attenuated sensitivity to apoptotic signaling, yet clinically relevant molecular actors to target mitochondria-mediated resistance remain elusive. Here, we show that MYC-driven neuroblastoma...
Autores principales: | Borankova, Karolina, Krchniakova, Maria, Leck, Lionel Y. W., Kubistova, Adela, Neradil, Jakub, Jansson, Patric J., Hogarty, Michael D., Skoda, Jan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654511/ https://www.ncbi.nlm.nih.gov/pubmed/37973789 http://dx.doi.org/10.1038/s41419-023-06278-x |
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