Isothermal chemical denaturation assay for monitoring protein stability and inhibitor interactions

Thermal shift assay (TSA) with altered temperature has been the most widely used method for monitoring protein stability for drug research. However, there is a pressing need for isothermal techniques as alternatives. This urgent demand arises from the limitations of TSA, which can sometimes provide...

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Detalles Bibliográficos
Autores principales: Mahran, Randa, Vello, Niklas, Komulainen, Anita, Malakoutikhah, Morteza, Härmä, Harri, Kopra, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654576/
https://www.ncbi.nlm.nih.gov/pubmed/37973851
http://dx.doi.org/10.1038/s41598-023-46720-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654576/
https://www.ncbi.nlm.nih.gov/pubmed/37973851
http://dx.doi.org/10.1038/s41598-023-46720-w

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