Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice

Atherosclerotic cardiovascular disease is characterized by both chronic low-grade inflammation and dyslipidemia. The AMP-activated protein kinase (AMPK) inhibits cholesterol synthesis and dampens inflammation but whether pharmacological activation reduces atherosclerosis is equivocal. In the current...

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Detalles Bibliográficos
Autores principales: Day, Emily A., Townsend, Logan K., Rehal, Sonia, Batchuluun, Battsetseg, Wang, Dongdong, Morrow, Marisa R., Lu, Rachel, Lundenberg, Lucie, Lu, Jessie H., Desjardins, Eric M., Smith, Tyler K.T., Raphenya, Amogelang R., McArthur, Andrew G., Fullerton, Morgan D., Steinberg, Gregory R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654588/
https://www.ncbi.nlm.nih.gov/pubmed/38026185
http://dx.doi.org/10.1016/j.isci.2023.108269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654588/
https://www.ncbi.nlm.nih.gov/pubmed/38026185
http://dx.doi.org/10.1016/j.isci.2023.108269

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