Nonfucosylation of an anti-TIGIT antibody enhances FcγR engagement, driving innate immune activation and antitumor activity

TIGIT is an immune checkpoint receptor expressed on activated and memory T cells, immunosuppressive T regulatory cells, and natural killer (NK) cells. TIGIT has emerged as an attractive target for antitumor therapies, due to its proposed immunosuppressive effects on lymphocyte function and T cell ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Alyson J., Thurman, Robert E., Zeng, Weiping, Grogan, Bryan, Lucas, Sasha, Gutierrez, Guadalupe, Heiser, Ryan A., Wo, Serena W., Blackmarr, Amber, Peterson, Scott, Gardai, Shyra J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654636/
https://www.ncbi.nlm.nih.gov/pubmed/38022590
http://dx.doi.org/10.3389/fimmu.2023.1280986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654636/
https://www.ncbi.nlm.nih.gov/pubmed/38022590
http://dx.doi.org/10.3389/fimmu.2023.1280986

Ejemplares similares