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Nonfucosylation of an anti-TIGIT antibody enhances FcγR engagement, driving innate immune activation and antitumor activity

TIGIT is an immune checkpoint receptor expressed on activated and memory T cells, immunosuppressive T regulatory cells, and natural killer (NK) cells. TIGIT has emerged as an attractive target for antitumor therapies, due to its proposed immunosuppressive effects on lymphocyte function and T cell ac...

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Detalles Bibliográficos
Autores principales:	Smith, Alyson J., Thurman, Robert E., Zeng, Weiping, Grogan, Bryan, Lucas, Sasha, Gutierrez, Guadalupe, Heiser, Ryan A., Wo, Serena W., Blackmarr, Amber, Peterson, Scott, Gardai, Shyra J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654636/ https://www.ncbi.nlm.nih.gov/pubmed/38022590 http://dx.doi.org/10.3389/fimmu.2023.1280986

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