Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells

Cognate interaction between CD4(+) effector memory T (T(EM)) cells and dendritic cells (DCs) induces innate inflammatory cytokine production, resulting in detrimental autoimmune pathology and cytokine storms. While T(EM) cells use tumor necrosis factor (TNF) superfamily ligands to activate DCs, whet...

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Detalles Bibliográficos
Autores principales: Meibers, Hannah E., Warrick, Kathrynne A., VonHandorf, Andrew, Vallez, Charles N., Kawarizadeh, Kiana, Saha, Irene, Donmez, Omer, Jain, Viral G., Kottyan, Leah C., Weirauch, Matthew T., Pasare, Chandrashekhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654673/
https://www.ncbi.nlm.nih.gov/pubmed/37794597
http://dx.doi.org/10.1016/j.celrep.2023.113180

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