Cargando…

Restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in Parkinson’s disease

Parkinson’s disease (PD) is a predominantly idiopathic pathological condition characterized by protein aggregation phenomena, whose main component is alpha-synuclein. Although the main risk factor is ageing, numerous evidence points to the role of type 2 diabetes mellitus (T2DM) as an etiological fa...

Descripción completa

Detalles Bibliográficos
Autores principales: Greco, Marco, Munir, Anas, Musarò, Debora, Coppola, Chiara, Maffia, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654753/
https://www.ncbi.nlm.nih.gov/pubmed/38027497
http://dx.doi.org/10.3389/fnins.2023.1244022
_version_ 1785136693945303040
author Greco, Marco
Munir, Anas
Musarò, Debora
Coppola, Chiara
Maffia, Michele
author_facet Greco, Marco
Munir, Anas
Musarò, Debora
Coppola, Chiara
Maffia, Michele
author_sort Greco, Marco
collection PubMed
description Parkinson’s disease (PD) is a predominantly idiopathic pathological condition characterized by protein aggregation phenomena, whose main component is alpha-synuclein. Although the main risk factor is ageing, numerous evidence points to the role of type 2 diabetes mellitus (T2DM) as an etiological factor. Systemic alterations classically associated with T2DM like insulin resistance and hyperglycemia modify biological processes such as autophagy and mitochondrial homeostasis. High glucose levels also compromise protein stability through the formation of advanced glycation end products, promoting protein aggregation processes. The ability of antidiabetic drugs to act on pathways impaired in both T2DM and PD suggests that they may represent a useful tool to counteract the neurodegeneration process. Several clinical studies now in advanced stages are looking for confirmation in this regard.
format Online
Article
Text
id pubmed-10654753
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-106547532023-01-01 Restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in Parkinson’s disease Greco, Marco Munir, Anas Musarò, Debora Coppola, Chiara Maffia, Michele Front Neurosci Neuroscience Parkinson’s disease (PD) is a predominantly idiopathic pathological condition characterized by protein aggregation phenomena, whose main component is alpha-synuclein. Although the main risk factor is ageing, numerous evidence points to the role of type 2 diabetes mellitus (T2DM) as an etiological factor. Systemic alterations classically associated with T2DM like insulin resistance and hyperglycemia modify biological processes such as autophagy and mitochondrial homeostasis. High glucose levels also compromise protein stability through the formation of advanced glycation end products, promoting protein aggregation processes. The ability of antidiabetic drugs to act on pathways impaired in both T2DM and PD suggests that they may represent a useful tool to counteract the neurodegeneration process. Several clinical studies now in advanced stages are looking for confirmation in this regard. Frontiers Media S.A. 2023-11-03 /pmc/articles/PMC10654753/ /pubmed/38027497 http://dx.doi.org/10.3389/fnins.2023.1244022 Text en Copyright © 2023 Greco, Munir, Musarò, Coppola and Maffia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Greco, Marco
Munir, Anas
Musarò, Debora
Coppola, Chiara
Maffia, Michele
Restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in Parkinson’s disease
title Restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in Parkinson’s disease
title_full Restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in Parkinson’s disease
title_fullStr Restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in Parkinson’s disease
title_full_unstemmed Restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in Parkinson’s disease
title_short Restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in Parkinson’s disease
title_sort restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in parkinson’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654753/
https://www.ncbi.nlm.nih.gov/pubmed/38027497
http://dx.doi.org/10.3389/fnins.2023.1244022
work_keys_str_mv AT grecomarco restoringautophagicfunctionacasefortype2diabetesmellitusdrugrepurposinginparkinsonsdisease
AT muniranas restoringautophagicfunctionacasefortype2diabetesmellitusdrugrepurposinginparkinsonsdisease
AT musarodebora restoringautophagicfunctionacasefortype2diabetesmellitusdrugrepurposinginparkinsonsdisease
AT coppolachiara restoringautophagicfunctionacasefortype2diabetesmellitusdrugrepurposinginparkinsonsdisease
AT maffiamichele restoringautophagicfunctionacasefortype2diabetesmellitusdrugrepurposinginparkinsonsdisease