Antibody-Proteolysis Targeting Chimera Conjugate Enables Selective Degradation of Receptor-Interacting Serine/Threonine-Protein Kinase 2 in HER2+ Cell Lines

[Image: see text] Proteolysis targeting chimeras (PROTACs) are a family of heterobifunctional molecules that are now realizing their promise as a therapeutic strategy for targeted protein degradation. However, one limitation of existing designs is the lack of cell-selective targeting of the protein...

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Detalles Bibliográficos
Autores principales: Chan, Karina, Sathyamurthi, Preethi Soundarya, Queisser, Markus A., Mullin, Michael, Shrives, Harry, Coe, Diane M., Burley, Glenn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655034/
https://www.ncbi.nlm.nih.gov/pubmed/37917829
http://dx.doi.org/10.1021/acs.bioconjchem.3c00366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655034/
https://www.ncbi.nlm.nih.gov/pubmed/37917829
http://dx.doi.org/10.1021/acs.bioconjchem.3c00366

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