CCL5 promotes LFA-1 expression in Th17 cells and induces LCK and ZAP70 activation in a mouse model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD), which is associated to autoimmune disorders, is characterized by the pathological deposition of alpha-synuclein (α-Syn) and loss of dopaminergic (DA) neurons. Th17 cells are thought to be responsible for the direct loss of DA neurons. C-C chemokine ligand 5 (CCL...

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Detalles Bibliográficos
Autores principales: Zhao, Jingwei, An, Ke, Mao, Zhijuan, Qu, Yi, Wang, Danlei, Li, Jiangting, Min, Zhe, Xue, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655117/
https://www.ncbi.nlm.nih.gov/pubmed/38020765
http://dx.doi.org/10.3389/fnagi.2023.1250685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655117/
https://www.ncbi.nlm.nih.gov/pubmed/38020765
http://dx.doi.org/10.3389/fnagi.2023.1250685

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