Acidification of intracellular pH in MM tumor cells overcomes resistance to hypoxia-mediated apoptosis in vitro and in vivo

INTRODUCTION: Multiple myeloma (MM) is an incurable cancer of malignant plasma cells that engraft in the bone marrow (BM). It is more than likely that the poorly investigated physical parameters of hypoxia and pH in the tumor microenvironment (TME) is critical for MM survival. Here, we explore the e...

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Detalles Bibliográficos
Autores principales: Gastelum, Gilberto, Kraut, Jeffry, Veena, Mysore, Baibussinov, Alisher, Lamb, Christopher, Lyons, Kylee, Chang, Eric Y., Frost, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655143/
https://www.ncbi.nlm.nih.gov/pubmed/38023253
http://dx.doi.org/10.3389/fonc.2023.1268421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655143/
https://www.ncbi.nlm.nih.gov/pubmed/38023253
http://dx.doi.org/10.3389/fonc.2023.1268421

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