The meaning of ubiquitylation of the DSL ligand Delta for the development of Drosophila

BACKGROUND: Ubiquitylation (ubi) of the intracellular domain of the Notch ligand Delta (Dl) by the E3 ligases Neuralized (Neur) and Mindbomb1 (Mib1) on lysines (Ks) is thought to be essential for the its signalling activity. Nevertheless, we have previously shown that DlK2R-HA, a Dl variant where al...

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Detalles Bibliográficos
Autores principales: Troost, Tobias, Seib, Ekaterina, Airich, Alina, Vüllings, Nicole, Necakov, Aleksandar, De Renzis, Stefano, Klein, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655352/
https://www.ncbi.nlm.nih.gov/pubmed/37974242
http://dx.doi.org/10.1186/s12915-023-01759-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655352/
https://www.ncbi.nlm.nih.gov/pubmed/37974242
http://dx.doi.org/10.1186/s12915-023-01759-z

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