Liver-X-receptor agonists rescue axonal degeneration in SPG11-deficient neurons via regulating cholesterol trafficking

Spastic paraplegia type 11 (SPG11) is a common autosomal recessive form of hereditary spastic paraplegia (HSP) characterized by the degeneration of cortical motor neuron axons, leading to muscle spasticity and weakness. Impaired lipid trafficking is an emerging pathology in neurodegenerative disease...

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Detalles Bibliográficos
Autores principales: Chai, Eric, Chen, Zhenyu, Mou, Yongchao, Thakur, Gitika, Zhan, Weihai, Li, Xue-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655618/
https://www.ncbi.nlm.nih.gov/pubmed/37709208
http://dx.doi.org/10.1016/j.nbd.2023.106293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655618/
https://www.ncbi.nlm.nih.gov/pubmed/37709208
http://dx.doi.org/10.1016/j.nbd.2023.106293

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