Cargando…
Multifactorial Remodeling of the Cancer Immunopeptidome by IFNγ
IFNγ alters the immunopeptidome presented on HLA class I (HLA-I), and its activity on cancer cells is known to be important for effective immunotherapy responses. We performed proteomic analyses of untreated and IFNγ-treated colorectal cancer patient-derived organoids and combined this with transcri...
Autores principales: | Newey, Alice, Yu, Lu, Barber, Louise J., Choudhary, Jyoti S., Bassani-Sternberg, Michal, Gerlinger, Marco |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655636/ https://www.ncbi.nlm.nih.gov/pubmed/37991387 http://dx.doi.org/10.1158/2767-9764.CRC-23-0121 |
Ejemplares similares
-
Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment
por: Newey, Alice, et al.
Publicado: (2019) -
Editorial: Immunopeptidomic Approaches for the Identification of Tumor (neo)Antigens
por: Lill, Jennie R., et al.
Publicado: (2022) -
High-throughput and Sensitive Immunopeptidomics Platform Reveals Profound Interferonγ-Mediated Remodeling of the Human Leukocyte Antigen (HLA) Ligandome
por: Chong, Chloe, et al.
Publicado: (2018) -
Current perspectives on mass spectrometry-based immunopeptidomics: the computational angle to tumor antigen discovery
por: Zhang, Bing, et al.
Publicado: (2023) -
A microfluidics-enabled automated workflow of sample preparation for MS-based immunopeptidomics
por: Li, Xiaokang, et al.
Publicado: (2023)