Sterol dysregulation in Smith–Lemli–Opitz syndrome causes astrocyte immune reactivity through microglia crosstalk

Owing to the need for de novo cholesterol synthesis and cholesterol-enriched structures within the nervous system, cholesterol homeostasis is critical to neurodevelopment. Diseases caused by genetic disruption of cholesterol biosynthesis, such as Smith–Lemli–Opitz syndrome, which is caused by mutati...

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Detalles Bibliográficos
Autores principales: Freel, Bethany A., Kelvington, Benjamin A., Sengupta, Sonali, Mukherjee, Malini, Francis, Kevin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655813/
https://www.ncbi.nlm.nih.gov/pubmed/36524414
http://dx.doi.org/10.1242/dmm.049843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655813/
https://www.ncbi.nlm.nih.gov/pubmed/36524414
http://dx.doi.org/10.1242/dmm.049843

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