Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation

Huntington disease (HD) is a neurodegenerative disease associated with polyglutamine expansion in the protein huntingtin (HTT). Although the length of the polyglutamine repeat correlates with age at disease onset and severity, psychological, cognitive and behavioral complications point to the existe...

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Detalles Bibliográficos
Autores principales: Pradhan, Sai S., Thota, Sai M., Rajaratnam, Saiswaroop, Bhagavatham, Sai K. S., Pulukool, Sujith K., Rathnakumar, Sriram, Phalguna, Kanikaram S., Dandamudi, Rajesh B., Pargaonkar, Ashish, Joseph, Prasanth, Joshy, E. V., Sivaramakrishnan, Venketesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655815/
https://www.ncbi.nlm.nih.gov/pubmed/36052548
http://dx.doi.org/10.1242/dmm.049492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655815/
https://www.ncbi.nlm.nih.gov/pubmed/36052548
http://dx.doi.org/10.1242/dmm.049492

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