17q12 deletion syndrome mouse model shows defects in craniofacial, brain and kidney development, and glucose homeostasis

17q12 deletion (17q12Del) syndrome is a copy number variant (CNV) disorder associated with neurodevelopmental disorders and renal cysts and diabetes syndrome (RCAD). Using CRISPR/Cas9 genome editing, we generated a mouse model of 17q12Del syndrome on both inbred (C57BL/6N) and outbred (CD-1) genetic...

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Detalles Bibliográficos
Autores principales: Warren, Emily B., Briano, Juan A., Ellegood, Jacob, DeYoung, Taylor, Lerch, Jason P., Morrow, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655816/
https://www.ncbi.nlm.nih.gov/pubmed/36373506
http://dx.doi.org/10.1242/dmm.049752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655816/
https://www.ncbi.nlm.nih.gov/pubmed/36373506
http://dx.doi.org/10.1242/dmm.049752

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