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BRASS: Permutation methods for binary traits in genetic association studies with structured samples

In genetic association analysis of complex traits, permutation testing can be a valuable tool for assessing significance when the distribution of the test statistic is unknown or not well-approximated. This commonly arises, e.g, in tests of gene-set, pathway or genome-wide significance, or when the...

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Detalles Bibliográficos
Autores principales: Mbatchou, Joelle, Abney, Mark, McPeek, Mary Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656004/
https://www.ncbi.nlm.nih.gov/pubmed/37934792
http://dx.doi.org/10.1371/journal.pgen.1011020