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The SMYD3-MAP3K2 signaling axis promotes tumor aggressiveness and metastasis in prostate cancer

Aberrant activation of Ras/Raf/mitogen-activated protein kinase (MAPK) signaling is frequently linked to metastatic prostate cancer (PCa); therefore, the characterization of modulators of this pathway is critical for defining therapeutic vulnerabilities for metastatic PCa. The lysine methyltransfera...

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Detalles Bibliográficos
Autores principales: Ikram, Sabeen, Rege, Apurv, Negesse, Maraki Y., Casanova, Alexandre G., Reynoird, Nicolas, Green, Erin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656069/
https://www.ncbi.nlm.nih.gov/pubmed/37976356
http://dx.doi.org/10.1126/sciadv.adi5921