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DOT1L is a barrier to histone acetylation during reprogramming to pluripotency
Embryonic stem cells (ESCs) have transcriptionally permissive chromatin enriched for gene activation–associated histone modifications. A striking exception is DOT1L-mediated H3K79 dimethylation (H3K79me2) that is considered a positive regulator of transcription. We find that ESCs are depleted for H3...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656071/ https://www.ncbi.nlm.nih.gov/pubmed/37976354 http://dx.doi.org/10.1126/sciadv.adf3980 |