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Deubiquitinase UCHL1 regulates estradiol synthesis by stabilizing voltage-dependent anion channel 2

Lack of estradiol production by granulosa cells blocks follicle development, causes failure of estrous initiation, and results in an inability to ovulate. The ubiquitin-proteasome system plays a critical role in maintaining protein homeostasis and stability of the estrous cycle, but knowledge of deu...

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Detalles Bibliográficos
Autores principales: Shi, Shengjie, Chu, Guiyan, Zhang, Lutong, Yuan, Huan, Madaniyati, Mielie, Zhou, Xiaoge, Wang, Liguang, Cai, Chuanjiang, Pang, Weijun, Gao, Lei, Yang, Gongshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656229/
https://www.ncbi.nlm.nih.gov/pubmed/37797697
http://dx.doi.org/10.1016/j.jbc.2023.105316