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Deubiquitinase UCHL1 regulates estradiol synthesis by stabilizing voltage-dependent anion channel 2
Lack of estradiol production by granulosa cells blocks follicle development, causes failure of estrous initiation, and results in an inability to ovulate. The ubiquitin-proteasome system plays a critical role in maintaining protein homeostasis and stability of the estrous cycle, but knowledge of deu...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656229/ https://www.ncbi.nlm.nih.gov/pubmed/37797697 http://dx.doi.org/10.1016/j.jbc.2023.105316 |