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Wolf-Hirschhorn syndrome candidate 1 (Whsc1) methyltransferase signals via a Pitx2-miR-23/24 axis to effect tooth development

Wolf-Hirschhorn syndrome (WHS) is a developmental disorder attributed to a partial deletion on the short arm of chromosome 4. WHS patients suffer from oral manifestations including cleft lip and palate, hypodontia, and taurodontism. WHS candidate 1 (WHSC1) gene is a H3K36-specific methyltransferase...

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Detalles Bibliográficos
Autores principales: Su, Dan, Eliason, Steve, Sun, Zhao, Shao, Fan, Amendt, Brad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656234/
https://www.ncbi.nlm.nih.gov/pubmed/37806494
http://dx.doi.org/10.1016/j.jbc.2023.105324