Programmable multispecific DNA-origami-based T-cell engagers

Multispecific antibodies have emerged as versatile therapeutic agents, and therefore, approaches to optimize and streamline their design and assembly are needed. Here we report on the modular and programmable assembly of IgG antibodies, F(ab) and scFv fragments on DNA origami nanocarriers. We screen...

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Detalles Bibliográficos
Autores principales: Wagenbauer, Klaus F., Pham, Nhi, Gottschlich, Adrian, Kick, Benjamin, Kozina, Viktorija, Frank, Christopher, Trninic, Daniela, Stömmer, Pierre, Grünmeier, Ruth, Carlini, Emanuele, Tsiverioti, Christina Angeliki, Kobold, Sebastian, Funke, Jonas J., Dietz, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656288/
https://www.ncbi.nlm.nih.gov/pubmed/37591933
http://dx.doi.org/10.1038/s41565-023-01471-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656288/
https://www.ncbi.nlm.nih.gov/pubmed/37591933
http://dx.doi.org/10.1038/s41565-023-01471-7

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