Protein-encapsulated doxorubicin reduces cardiotoxicity in hiPSC-cardiomyocytes and cardiac spheroids while maintaining anticancer efficacy

The chemotherapeutic doxorubicin (DOX) detrimentally impacts the heart during cancer treatment. This necessitates development of non-cardiotoxic delivery systems that retain DOX anticancer efficacy. We used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), endothelial cells (hi...

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Detalles Bibliográficos
Autores principales: Arzt, Madelyn, Gao, Bowen, Mozneb, Maedeh, Pohlman, Stephany, Cejas, Romina B., Liu, Qizhi, Huang, Faqing, Yu, Changjun, Zhang, Yi, Fan, Xuemo, Jenkins, Amelia, Giuliano, Armando E., Burridge, Paul W., Cui, Xiaojiang, Sharma, Arun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656302/
https://www.ncbi.nlm.nih.gov/pubmed/37657447
http://dx.doi.org/10.1016/j.stemcr.2023.08.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656302/
https://www.ncbi.nlm.nih.gov/pubmed/37657447
http://dx.doi.org/10.1016/j.stemcr.2023.08.005

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