Surface functionalization affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model

Besides the many advantages of oral drug administration, challenges like premature drug degradation and limited bioavailability in the gastro-intestinal tract (GIT) remain. A prolonged residence time in the GIT is beneficial for enhancing the therapeutic outcome when treating diseases associated wit...

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Detalles Bibliográficos
Autores principales: Schmid, Roman, Volcic, Meta, Fischer, Stephan, Qu, Zhi, Barth, Holger, Popat, Amirali, Kirchhoff, Frank, Lindén, Mika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656483/
https://www.ncbi.nlm.nih.gov/pubmed/37978264
http://dx.doi.org/10.1038/s41598-023-47445-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656483/
https://www.ncbi.nlm.nih.gov/pubmed/37978264
http://dx.doi.org/10.1038/s41598-023-47445-6

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