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Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids

Non-natural amino acids are increasingly used as building blocks in the development of peptide-based drugs as they expand the available chemical space to tailor function, half-life and other key properties. However, while the chemical space of modified amino acids (mAAs) such as residues containing...

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Detalles Bibliográficos
Autores principales: Oeller, Marc, Kang, Ryan J. D., Bolt, Hannah L., Gomes dos Santos, Ana L., Weinmann, Annika Langborg, Nikitidis, Antonios, Zlatoidsky, Pavol, Su, Wu, Czechtizky, Werngard, De Maria, Leonardo, Sormanni, Pietro, Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656490/
https://www.ncbi.nlm.nih.gov/pubmed/37978172
http://dx.doi.org/10.1038/s41467-023-42940-w