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PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice

BACKGROUND: Due to high rates of incidence and disability, postoperative cognitive dysfunction (POCD) currently receives a lot of clinical attention. Disturbance of fatty acid oxidation is a potential pathophysiological manifestation underlying POCD. Peroxisome proliferator-activated receptor α (PPA...

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Detalles Bibliográficos
Autores principales: Liu, Tiantian, Chen, Xinlu, Wei, Ziqi, Han, Xue, Liu, Yujia, Ma, Zhengliang, Xia, Tianjiao, Gu, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656729/
https://www.ncbi.nlm.nih.gov/pubmed/38023298
http://dx.doi.org/10.1515/tnsci-2022-0317