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BRD4 facilitates osteogenic differentiation of human bone marrow mesenchymal stem cells through WNT4/NF-κB pathway

BACKGROUND: Human bone marrow mesenchymal stem cells (hBMSCs) are a major source of osteoblast precursor cells and are directly involved in osteoporosis (OP) progression. Bromodomain-containing protein 4 (BRD4) is an important regulator for osteogenic differentiation. Therefore, its role and mechani...

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Detalles Bibliográficos
Autores principales: Ning, Tao, Guo, Huihui, Ma, Mingming, Zha, Zhengang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656925/
https://www.ncbi.nlm.nih.gov/pubmed/37980502
http://dx.doi.org/10.1186/s13018-023-04335-x