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How to fix DNA breaks: new insights into the mechanism of non-homologous end joining

Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation-induced DNA double-strand breaks (DSBs) in human cells and is essential for the generation of mature T and B cells in the adaptive immune system via the process of V(D)J recombination. Here, we review how rec...

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Detalles Bibliográficos
Autores principales: Vogt, Alex, He, Yuan, Lees-Miller, Susan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657183/
https://www.ncbi.nlm.nih.gov/pubmed/37787023
http://dx.doi.org/10.1042/BST20220741