Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma

Chimeric Antigen Receptor (CAR) T cells directed to B cell maturation antigen (BCMA) mediate profound responses in patients with multiple myeloma, but most patients do not achieve long-term complete remissions. In addition, recent evidence suggests that high-affinity binding to BCMA can result in on...

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Detalles Bibliográficos
Autores principales: Larson, Rebecca C., Kann, Michael C., Graham, Charlotte, Mount, Christopher W., Castano, Ana P., Lee, Won-Ho, Bouffard, Amanda A., Takei, Hana N., Almazan, Antonio J., Scarfó, Irene, Berger, Trisha R., Schmidts, Andrea, Frigault, Matthew J., Gallagher, Kathleen M. E., Maus, Marcela V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657357/
https://www.ncbi.nlm.nih.gov/pubmed/37980341
http://dx.doi.org/10.1038/s41467-023-43416-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657357/
https://www.ncbi.nlm.nih.gov/pubmed/37980341
http://dx.doi.org/10.1038/s41467-023-43416-7

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