Selectivity matters: selective ROCK2 inhibitor ameliorates established liver fibrosis via targeting inflammation, fibrosis, and metabolism

The pathogenesis of hepatic fibrosis is driven by dysregulated metabolism precipitated by chronic inflammation. Rho-associated coiled-coil-containing protein kinases (ROCKs) have been implicated in these processes, however the ability of selective ROCK2 inhibition to target simultaneously profibroti...

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Detalles Bibliográficos
Autores principales: Zanin-Zhorov, Alexandra, Chen, Wei, Moretti, Julien, Nyuydzefe, Melanie S., Zhorov, Iris, Munshi, Rashmi, Ghosh, Malavika, Serdjebi, Cindy, MacDonald, Kelli, Blazar, Bruce R., Palmer, Melissa, Waksal, Samuel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657369/
https://www.ncbi.nlm.nih.gov/pubmed/37980369
http://dx.doi.org/10.1038/s42003-023-05552-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657369/
https://www.ncbi.nlm.nih.gov/pubmed/37980369
http://dx.doi.org/10.1038/s42003-023-05552-0

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