Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT

Sodium-dependent glucose transporters (SGLTs) couple a downhill Na(+) ion gradient to actively transport sugars. Here, we investigate the impact of the membrane potential on vSGLT structure and function using sugar uptake assays, double electron-electron resonance (DEER), electrostatic calculations,...

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Detalles Bibliográficos
Autores principales: Khan, Farha, Elgeti, Matthias, Grandfield, Samuel, Paz, Aviv, Naughton, Fiona B., Marcoline, Frank V., Althoff, Thorsten, Ermolova, Natalia, Wright, Ernest M., Hubbell, Wayne L., Grabe, Michael, Abramson, Jeff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657379/
https://www.ncbi.nlm.nih.gov/pubmed/37980423
http://dx.doi.org/10.1038/s41467-023-43119-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657379/
https://www.ncbi.nlm.nih.gov/pubmed/37980423
http://dx.doi.org/10.1038/s41467-023-43119-z

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