The oncogenic fusion protein TAZ::CAMTA1 promotes genomic instability and senescence through hypertranscription

TAZ::CAMTA1 is a fusion protein found in over 90% of Epithelioid Hemangioendothelioma (EHE), a rare vascular sarcoma with an unpredictable disease course. To date, how TAZ::CAMTA1 initiates tumour formation remains unexplained. To study the oncogenic mechanism leading to EHE initiation, we developed...

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Detalles Bibliográficos
Autores principales: Neil, Emily, Paredes, Roberto, Pooley, Oscar, Rubin, Brian, Kouskoff, Valerie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657451/
https://www.ncbi.nlm.nih.gov/pubmed/37980390
http://dx.doi.org/10.1038/s42003-023-05540-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657451/
https://www.ncbi.nlm.nih.gov/pubmed/37980390
http://dx.doi.org/10.1038/s42003-023-05540-4

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