The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes

TOP3B is stabilized by TDRD3. Hypothesizing that TDRD3 recruits a deubiquitinase, we find that TOP3B interacts with USP9X via TDRD3. Inactivation of USP9X destabilizes TOP3B, and depletion of both TDRD3 and USP9X does not promote further TOP3B ubiquitylation. Additionally, we observe that MIB1 media...

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Detalles Bibliográficos
Autores principales: Saha, Sourav, Huang, Shar-yin Naomi, Yang, Xi, Saha, Liton Kumar, Sun, Yilun, Khandagale, Prashant, Jenkins, Lisa M., Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657456/
https://www.ncbi.nlm.nih.gov/pubmed/37980342
http://dx.doi.org/10.1038/s41467-023-43151-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657456/
https://www.ncbi.nlm.nih.gov/pubmed/37980342
http://dx.doi.org/10.1038/s41467-023-43151-z

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