Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles

Although mRNA lipid nanoparticles (LNPs) are highly effective as vaccines, their efficacy for pulmonary delivery has not yet fully been established. A major barrier to this therapeutic goal is their instability during aerosolization for local delivery. This imparts a shear force that degrades the mR...

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Detalles Bibliográficos
Autores principales: Lewis, Mae M., Soto, Melissa R., Maier, Esther Y., Wulfe, Steven D., Bakheet, Sandy, Obregon, Hannah, Ghosh, Debadyuti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Regular Issue Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658486/
https://www.ncbi.nlm.nih.gov/pubmed/38023707
http://dx.doi.org/10.1002/btm2.10580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658486/
https://www.ncbi.nlm.nih.gov/pubmed/38023707
http://dx.doi.org/10.1002/btm2.10580

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