An engineered interleukin‐11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma

The cytokine interleukin (IL)‐11 has been shown to play a role in promoting fibrosis and cancer, including lung adenocarcinoma, garnering interest as an attractive target for therapeutic intervention. We used combinatorial methods to engineer an IL‐11 variant that binds with higher affinity to the I...

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Detalles Bibliográficos
Autores principales: McIntosh, Brianna J., Hartmann, Griffin G., Yamada‐Hunter, Sean A., Liu, Phillip, Williams, Camille F., Sage, Julien, Cochran, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Regular Issue Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658506/
https://www.ncbi.nlm.nih.gov/pubmed/38023717
http://dx.doi.org/10.1002/btm2.10573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658506/
https://www.ncbi.nlm.nih.gov/pubmed/38023717
http://dx.doi.org/10.1002/btm2.10573

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