Novel piperazine‐based ionizable lipid nanoparticles allow the repeated dose of mRNA to fibrotic lungs with improved potency and safety

mRNA‐based protein replacement therapy has received much attention as a novel intervention in clinical disease treatment. Lipid nanoparticles (LNPs) are widely used for their therapeutic potential to efficiently deliver mRNA. However, clinical translation has been hampered by the immunogenicity of L...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Minjeong, Jeong, Michaela, Lee, Gyeongseok, Lee, Yeji, Park, Jeongeun, Jung, Hyein, Im, Seongeun, Yang, Joo‐Sung, Kim, Kyungjin, Lee, Hyukjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Special Issue Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658549/
https://www.ncbi.nlm.nih.gov/pubmed/38023699
http://dx.doi.org/10.1002/btm2.10556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658549/
https://www.ncbi.nlm.nih.gov/pubmed/38023699
http://dx.doi.org/10.1002/btm2.10556

Ejemplares similares