Prevalent and Disseminated Recombinant and Wild-Type Adeno-Associated Virus Integration in Macaques and Humans

Integration of naturally occurring adeno-associated viruses (AAV; wild-type AAV [wtAAV]) and those used in gene therapy (recombinant AAV [rAAV]) into host genomic DNA has been documented for over two decades. Results from mouse and dog studies have raised concerns of insertional mutagenesis and clon...

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Detalles Bibliográficos
Autores principales: Martins, Kelly M., Breton, Camilo, Zheng, Qi, Zhang, Zhe, Latshaw, Caitlin, Greig, Jenny A., Wilson, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659022/
https://www.ncbi.nlm.nih.gov/pubmed/37930949
http://dx.doi.org/10.1089/hum.2023.134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659022/
https://www.ncbi.nlm.nih.gov/pubmed/37930949
http://dx.doi.org/10.1089/hum.2023.134

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