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Differential vascular endothelial cell toxicity of established and novel BCR-ABL tyrosine kinase inhibitors

BCR-ABL tyrosine kinase inhibitors (TKIs) have dramatically improved survival in Philadelphia chromosome-positive leukemias. Newer BCR-ABL TKIs provide superior cancer outcomes but with increased risk of acute arterial thrombosis, which further increases in patients with cardiovascular comorbidities...

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Detalles Bibliográficos
Autores principales: Wang, Yihua, Travers, Richard J., Farrell, Alanna, Lu, Qing, Bays, Jennifer L., Stepanian, Alec, Chen, Christopher, Jaffe, Iris Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659179/
https://www.ncbi.nlm.nih.gov/pubmed/37983208
http://dx.doi.org/10.1371/journal.pone.0294438