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A simple Turing reaction–diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly
Centrioles duplicate when a mother centriole gives birth to a daughter that grows from its side. Polo-like-kinase 4 (PLK4), the master regulator of centriole duplication, is recruited symmetrically around the mother centriole, but it then concentrates at a single focus that defines the daughter cent...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659181/ https://www.ncbi.nlm.nih.gov/pubmed/37983248 http://dx.doi.org/10.1371/journal.pbio.3002391 |