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Spt5 C-terminal repeat domain phosphorylation and length negatively regulate heterochromatin through distinct mechanisms
Heterochromatin is a condensed chromatin structure that represses transcription of repetitive DNA elements and developmental genes, and is required for genome stability. Paradoxically, transcription of heterochromatic sequences is required for establishment of heterochromatin in diverse eukaryotic s...
Autores principales: | MacKinnon, Sarah, Pagé, Viviane, Chen, Jennifer J., Shariat-Panahi, Ali, Martin, Ryan D., Hébert, Terence E., Tanny, Jason C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659198/ https://www.ncbi.nlm.nih.gov/pubmed/37939109 http://dx.doi.org/10.1371/journal.pgen.1010492 |
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