Cargando…

Targeting Angiotensinogen With N-Acetylgalactosamine–Conjugated Small Interfering RNA to Reduce Blood Pressure

Blood pressure management involves antihypertensive therapies blocking the renin-angiotensin system (RAS). Yet, it might be inadequate due to poor patient adherence or the so-called RAS escape phenomenon, elicited by the compensatory renin elevation upon RAS blockade. Recently, evidence points towar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Dien, Cruz-López, Edwyn O., Tu, Ho-Chou, Zlatev, Ivan, Danser, A.H. Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2023
Materias:	ATVB in Focus: Emerging Genomic-Based Therapies for Cardiovascular Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659251/ https://www.ncbi.nlm.nih.gov/pubmed/37855126 http://dx.doi.org/10.1161/ATVBAHA.123.319897

Ejemplares similares

Angiotensinogen Suppression: A New Tool to Treat Cardiovascular and Renal Disease
por: Cruz-López, Edwyn O., et al.
Publicado: (2022)

Macrophages in Atherosclerosis Regression
por: Barrett, Tessa J.
Publicado: (2020)

Heterogeneity of T Cells in Atherosclerosis Defined by Single-Cell RNA-Sequencing and Cytometry by Time of Flight
por: Winkels, Holger, et al.
Publicado: (2020)

Measuring Arterial Stiffness in Animal Experimental Studies
por: Butlin, Mark, et al.
Publicado: (2020)

Plasma Pharmacokinetics of N-Acetylgalactosamine-Conjugated Small-Interfering Ribonucleic Acids (GalNAc-Conjugated siRNAs)
por: Sten, Sebastian, et al.
Publicado: (2023)

Blood pressure‐independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes
por: Cruz‐López, Edwyn O., et al.
Publicado: (2022)

Renin-Angiotensin System and Cardiovascular Functions
por: Wu, Chia-Hua, et al.
Publicado: (2018)

Reactive Sulfur Species: A New Redox Player in Cardiovascular Pathophysiology
por: Kolluru, Gopi K., et al.
Publicado: (2020)

Novel Antiplatelet Therapies for Atherothrombotic Diseases
por: Majithia, Arjun, et al.
Publicado: (2019)

Conventional Vasopressor and Vasopressor‐Sparing Strategies to Counteract the Blood Pressure–Lowering Effect of Small Interfering RNA Targeting Angiotensinogen
por: Uijl, Estrellita, et al.
Publicado: (2022)

(18)F-Sodium Fluoride ((18)F-NaF) for Imaging Microcalcification Activity in the Cardiovascular System
por: Tzolos, Evangelos, et al.
Publicado: (2020)

Angiotensinogen and the Modulation of Blood Pressure
por: Shu, Zimei, et al.
Publicado: (2021)

Liver-Targeted Delivery of Oligonucleotides with N-Acetylgalactosamine Conjugation
por: Cui, Hao, et al.
Publicado: (2021)

The therapeutic prospects of N-acetylgalactosamine-siRNA conjugates
por: Zhang, Lei, et al.
Publicado: (2022)

2018 George Lyman Duff Memorial Lecture: Genetics and Genomics of Coronary Artery Disease: A Decade of Progress
por: McPherson, Ruth
Publicado: (2019)

Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins
por: Zhou, Yaxian, et al.
Publicado: (2021)

Antisense oligonucleotides targeting hepatic angiotensinogen reduce atherosclerosis and liver steatosis in hypercholesterolemic mice
por: Ye, Dien, et al.
Publicado: (2023)

The N‐Acetylgalactosamine‐conjugated small interfering RNA inclisiran can be coadministered safely with atorvastatin in cynomolgus monkeys resulting in additive low‐density lipoprotein cholesterol reductions
por: Lehoux, Dario, et al.
Publicado: (2023)

Angiotensinogen gene polymorphism and ischemic stroke in East Asians: A meta-analysis☆
por: Wang, Sheng, et al.
Publicado: (2013)

Impact of spontaneous liposome modification with phospholipid polymer-lipid conjugates on protein interactions
por: Suzuki, Haruna, et al.
Publicado: (2022)

Special Collection on Electroporation-Based Therapies: A Selection of Papers From the Second World Congress on Electroporation
por: Heller, Richard, et al.
Publicado: (2019)

Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts
por: Ferrario, Carlos M., et al.
Publicado: (2019)

Bone morphogenetic protein 4 in perivascular adipose tissue ameliorates hypertension through regulation of angiotensinogen
por: Mu, Wen-Juan, et al.
Publicado: (2022)

Small Interfering RNA Therapeutics in Hypertension: A Viewpoint on Vasopressor and Vasopressor‐Sparing Strategies for Counteracting Blood Pressure Lowering by Angiotensinogen–Targeting Small Interfering RNA
por: Ranasinghe, Priyanga, et al.
Publicado: (2022)

Omadacycline Enters the Ring: A New Antimicrobial Contender
por: Barber, Katie E., et al.
Publicado: (2018)

Survival of patients with chronic heart failure in the community: a systematic review and meta‐analysis
por: Jones, Nicholas R., et al.
Publicado: (2019)

Thematic analysis of therapists' experiences integrating EMDR and EFT in couple therapy: Theoretical and clinical complementarity, and benefits to client couples
por: Linder, Jason N., et al.
Publicado: (2022)

Bio-Plex immunoassay measuring the quantity of lysosomal N-acetylgalactosamine-6-sulfatase protein in dried blood spots for the screening of mucopolysaccharidosis IVA in newborn: a pilot study
por: Chuang, Chih-Kuang, et al.
Publicado: (2017)

Dasatinib: the emerging evidence of its potential in the treatment of chronic myeloid leukemia
por: Haslam, Sonya
Publicado: (2005)

FTY720 in multiple sclerosis: the emerging evidence of its therapeutic value
por: Thomson, Andrew
Publicado: (2006)

K-111: the emerging evidence for its potential in the treatment of the metabolic syndrome
por: Duggan-Keen, Margaret
Publicado: (2006)

Eltrombopag: the emerging evidence of its therapeutic value in thrombocytopenia
por: Profit, Louise
Publicado: (2006)

Comparative Effectiveness of Cheonwangbosimdan (Tian Wang Bu Xin Dan) Versus Cognitive-Behavioral Therapy for Insomnia in Cancer Patients: A Randomized, Controlled, Open-Label, Parallel-Group, Pilot Trial
por: Moon, Sun-Young, et al.
Publicado: (2020)

Role of Bee Venom and Melittin on Restraining Angiogenesis and Metastasis in γ-Irradiated Solid Ehrlich Carcinoma-Bearing Mice
por: El Bakary, Nermeen M., et al.
Publicado: (2020)

Long-Term Effect of a Nonrandomized Psychosocial Mindfulness-Based Intervention in Hispanic/Latina Breast Cancer Survivors
por: Elimimian, Elizabeth, et al.
Publicado: (2020)

The Role of Ketogenic Diet in the Treatment of Neuroblastoma
por: Makuku, Rangarirai, et al.
Publicado: (2023)

Nurse-Administered Auricular Point Acupressure for Cancer-Related Pain
por: Van de Castle, Barb, et al.
Publicado: (2023)

The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion
por: Dembitz, Vilma, et al.
Publicado: (2019)

Structure and functions of angiotensinogen
por: Lu, Hong, et al.
Publicado: (2016)

Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes
por: Villota, Claudio, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_5nr7vofdrntk62h98d7aeb7ldb