A novel mouse model of cerebral adrenoleukodystrophy highlights NLRP3 activity in lesion pathogenesis

OBJECTIVE: We sought to create and characterize a mouse model of the inflammatory, cerebral demyelinating phenotype of X-linked adrenoleukodystrophy (ALD) that would facilitate the study of disease pathogenesis and therapy development. We also sought to cross-validate potential therapeutic targets s...

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Detalles Bibliográficos
Autores principales: Hashemi, Ezzat, Narain Srivastava, Isha, Aguirre, Alejandro, Tilahan Yoseph, Ezra, Kaushal, Esha, Awani, Avni, Kyu. Ryu, Jae, Akassoglou, Katerina, Talebian, Shahrzad, Chu, Pauline, Pisani, Laura, Musolino, Patricia, Steinman, Lawrence, Doyle, Kristian, Robinson, William H, Sharpe, Orr, Cayrol, Romain, Orchard, Paul, Lund, Troy, Vogel, Hannes, Lenail, Max, Han, May Htwe, Bonkowsky, Joshua Leith, Van Haren, Keith P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659266/
https://www.ncbi.nlm.nih.gov/pubmed/37986739
http://dx.doi.org/10.1101/2023.11.07.564025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659266/
https://www.ncbi.nlm.nih.gov/pubmed/37986739
http://dx.doi.org/10.1101/2023.11.07.564025

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