Systematic Dissection of Sequence Features Affecting the Binding Specificity of a Pioneer Factor Reveals Binding Synergy Between FOXA1 and AP-1

Despite the unique ability of pioneer transcription factors (PFs) to target nucleosomal sites in closed chromatin, they only bind a small fraction of their genomic motifs. The underlying mechanism of this selectivity is not well understood. Here, we design a high-throughput assay called ChIP-ISO to...

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Detalles Bibliográficos
Autores principales: Xu, Cheng, Kleinschmidt, Holly, Yang, Jianyu, Leith, Erik, Johnson, Jenna, Tan, Song, Mahony, Shaun, Bai, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659273/
https://www.ncbi.nlm.nih.gov/pubmed/37986839
http://dx.doi.org/10.1101/2023.11.08.566246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659273/
https://www.ncbi.nlm.nih.gov/pubmed/37986839
http://dx.doi.org/10.1101/2023.11.08.566246

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