TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids

In the nascent mesoderm, levels of Brachyury (TBXT) expression must be precisely regulated to ensure cells exit the primitive streak and pattern the anterior-posterior axis, but how this varying dosage informs morphogenesis is not well understood. In this study, we define the transcriptional consequ...

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Detalles Bibliográficos
Autores principales: Bulger, Emily A., Muncie-Vasic, Ivana, Libby, Ashley R.G., McDevitt, Todd C., Bruneau, Benoit G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659276/
https://www.ncbi.nlm.nih.gov/pubmed/37986746
http://dx.doi.org/10.1101/2023.11.06.565933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659276/
https://www.ncbi.nlm.nih.gov/pubmed/37986746
http://dx.doi.org/10.1101/2023.11.06.565933

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