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Evolutionary origin and structural ligand mimicry by the inserted domain of alpha-integrin proteins
Heterodimeric integrin proteins transmit signals through conformational changes upon ligand binding between their alpha (α) and beta (β) subunits. Early in chordate evolution, some α subunits acquired an “inserted” (I) domain, which expanded their ligand binding capacity but simultaneously obstructe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659397/ https://www.ncbi.nlm.nih.gov/pubmed/37986796 http://dx.doi.org/10.1101/2023.11.05.565221 |