Concurrent RB1 loss and BRCA-deficiency predicts enhanced immunological response and long-term survival in tubo-ovarian high-grade serous carcinoma

BACKGROUND: Somatic loss of the tumour suppressor RB1 is a common event in tubo-ovarian high-grade serous carcinoma (HGSC), which frequently co-occurs with alterations in homologous recombination DNA repair genes including BRCA1 and BRCA2 (BRCA). We examined whether tumour expression of RB1 was asso...

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Autores principales: Saner, Flurina A. M., Takahashi, Kazuaki, Budden, Timothy, Pandey, Ahwan, Ariyaratne, Dinuka, Zwimpfer, Tibor A., Meagher, Nicola S., Fereday, Sian, Twomey, Laura, Pishas, Kathleen I., Hoang, Therese, Bolithon, Adelyn, Traficante, Nadia, Alsop, Kathryn, Christie, Elizabeth L., Kang, Eun-Young, Nelson, Gregg S., Ghatage, Prafull, Lee, Cheng-Han, Riggan, Marjorie J., Alsop, Jennifer, Beckmann, Matthias W., Boros, Jessica, Brand, Alison H., Brooks-Wilson, Angela, Carney, Michael E., Coulson, Penny, Courtney-Brooks, Madeleine, Cushing-Haugen, Kara L., Cybulski, Cezary, El-Bahrawy, Mona A., Elishaev, Esther, Erber, Ramona, Gayther, Simon A., Gentry-Maharaj, Aleksandra, Blake Gilks, C., Harnett, Paul R., Harris, Holly R., Hartmann, Arndt, Hein, Alexander, Hendley, Joy, Hernandez, Brenda Y., Jakubowska, Anna, Jimenez-Linan, Mercedes, Jones, Michael E., Kaufmann, Scott H., Kennedy, Catherine J., Kluz, Tomasz, Koziak, Jennifer M., Kristjansdottir, Björg, Le, Nhu D., Lener, Marcin, Lester, Jenny, Lubiński, Jan, Mateoiu, Constantina, Orsulic, Sandra, Ruebner, Matthias, Schoemaker, Minouk J., Shah, Mitul, Sharma, Raghwa, Sherman, Mark E., Shvetsov, Yurii B., Singh, Naveena, Rinda Soong, T., Steed, Helen, Sukumvanich, Paniti, Talhouk, Aline, Taylor, Sarah E., Vierkant, Robert A., Wang, Chen, Widschwendter, Martin, Wilkens, Lynne R., Winham, Stacey J., Anglesio, Michael S., Berchuck, Andrew, Brenton, James D., Campbell, Ian, Cook, Linda S., Doherty, Jennifer A., Fasching, Peter A., Fortner, Renée T., Goodman, Marc T., Gronwald, Jacek, Huntsman, David G., Karlan, Beth Y., Kelemen, Linda E., Menon, Usha, Modugno, Francesmary, Pharoah, Paul D.P., Schildkraut, Joellen M., Sundfeldt, Karin, Swerdlow, Anthony J., Goode, Ellen L., DeFazio, Anna, Köbel, Martin, Ramus, Susan J., Bowtell, David D. L., Garsed, Dale W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659507/
https://www.ncbi.nlm.nih.gov/pubmed/37986741
http://dx.doi.org/10.1101/2023.11.09.23298321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659507/
https://www.ncbi.nlm.nih.gov/pubmed/37986741
http://dx.doi.org/10.1101/2023.11.09.23298321

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