PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer’s disease

The recently discovered interaction between presenilin 1 (PS1), a catalytic subunit of γ-secretase responsible for the generation of amyloid-β(Aβ) peptides, and GLT-1, the major glutamate transporter in the brain (EAAT2 in the human) may provide a mechanistic link between two important pathological...

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Detalles Bibliográficos
Autores principales: Perrin, Florian, Anderson, Lauren C., Mitchell, Shane P.C., Sinha, Priyanka, Turchyna, Yuliia, Maesako, Masato, Houser, Mei C.Q., Zhang, Can, Wagner, Steven L., Tanzi, Rudolph E., Berezovska, Oksana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659539/
https://www.ncbi.nlm.nih.gov/pubmed/37986905
http://dx.doi.org/10.21203/rs.3.rs-3495211/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659539/
https://www.ncbi.nlm.nih.gov/pubmed/37986905
http://dx.doi.org/10.21203/rs.3.rs-3495211/v1

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