The potential clinical impact of cell type‐specific genetic regulation: Crohn's disease

Complex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome‐wide association studies (GWAS) integrated with single‐cell expression quantitative trait loci analyses (eQTL) can pinpoint cell‐type specific candidate...

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Detalles Bibliográficos
Autores principales: Tyebally, Rika, Xue, Angli, Powell, Joseph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659767/
https://www.ncbi.nlm.nih.gov/pubmed/37983917
http://dx.doi.org/10.1002/ctm2.1474
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author Tyebally, Rika
Xue, Angli
Powell, Joseph E.
author_facet Tyebally, Rika
Xue, Angli
Powell, Joseph E.
author_sort Tyebally, Rika
collection PubMed
description Complex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome‐wide association studies (GWAS) integrated with single‐cell expression quantitative trait loci analyses (eQTL) can pinpoint cell‐type specific candidate disease‐relevant genes and pathways. This knowledge can be applied to patient stratification and novel therapeutic target identification. Here, we describe the translational potential of cell‐type specific genetic regulation, using Crohn's disease as an example.
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spelling pubmed-106597672023-11-20 The potential clinical impact of cell type‐specific genetic regulation: Crohn's disease Tyebally, Rika Xue, Angli Powell, Joseph E. Clin Transl Med Short Communication Complex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome‐wide association studies (GWAS) integrated with single‐cell expression quantitative trait loci analyses (eQTL) can pinpoint cell‐type specific candidate disease‐relevant genes and pathways. This knowledge can be applied to patient stratification and novel therapeutic target identification. Here, we describe the translational potential of cell‐type specific genetic regulation, using Crohn's disease as an example. John Wiley and Sons Inc. 2023-11-20 /pmc/articles/PMC10659767/ /pubmed/37983917 http://dx.doi.org/10.1002/ctm2.1474 Text en © 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Tyebally, Rika
Xue, Angli
Powell, Joseph E.
The potential clinical impact of cell type‐specific genetic regulation: Crohn's disease
title The potential clinical impact of cell type‐specific genetic regulation: Crohn's disease
title_full The potential clinical impact of cell type‐specific genetic regulation: Crohn's disease
title_fullStr The potential clinical impact of cell type‐specific genetic regulation: Crohn's disease
title_full_unstemmed The potential clinical impact of cell type‐specific genetic regulation: Crohn's disease
title_short The potential clinical impact of cell type‐specific genetic regulation: Crohn's disease
title_sort potential clinical impact of cell type‐specific genetic regulation: crohn's disease
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659767/
https://www.ncbi.nlm.nih.gov/pubmed/37983917
http://dx.doi.org/10.1002/ctm2.1474
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